Thinking laterally about neurodegenerative proteinopathies

Thinking laterally about neurodegenerative proteinopathies.

Many neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and frontotemporal dementia, are proteinopathies that are associated with the aggregation and accumulation of misfolded proteins. While remarkable progress has been made in understanding the triggers of these conditions, several challenges have hampered the translation of preclinical ther...

Thinking laterally about genomes.

Perhaps the most-surprising discovery of the genome era has been the extent to which prokaryotic and many eukaryotic genomes incorporate genetic material from sources other than their parent(s). Lateral genetic transfer (LGT) among bacteria was first observed about 100 years ago, and is now accepted to underlie important phenomena including the spread of antibiotic resistance and ability to deg...

Chronic traumatic encephalopathy and other neurodegenerative proteinopathies

"Chronic traumatic encephalopathy" (CTE) is described as a slowly progressive neurodegenerative disease believed to result from multiple concussions. Traditionally, concussions were considered benign events and although most people recover fully, about 10% develop a post-concussive syndrome with persisting neurological, cognitive and neuropsychiatric symptoms. CTE was once thought to be unique ...

Correction: Proteinopathies and OXPHOS dysfunction in neurodegenerative diseases

Thinking slow about thinking fast

In his book, Thinking, Fast and Slow, Daniel Kahneman attributes experientially-learned real-world coping skills to an " associative machine " acting on declarative memories of facts and events. While this attribution is probably correct for the unfamiliar types of situations that are the subject of his famous experiments conducted with Amos Tversky, we argue that experientially-learned real-wo...